Researchers develop a new class of CAR-T cells that target previously untargetable cancer drivers

In a breakthrough for the treatment of aggressive solid cancers, researchers have developed a novel cancer therapy that targets proteins inside cancer cells that are essential for tumor growth and survival but have been historically impossible to reach. Using the power of large data sets and advanced computational approaches, the researchers were able to identify peptides that are presented on the surface of tumor cells and can be targeted with 'peptide-centric' chimeric antigen receptors (PC-CARs), a new class of engineered T cells, stimulating an immune response that eradicates tumors.

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